检索范围:
排序: 展示方式:
Association study on GNB3 gene polymorphism with essential hypertension in Xinjiang Uygur group
JING Jianying, WANG Dan, WANG Xiaofeng, JIN Jianzhong, JIN Li, JIAO Yi, WEN Hao, LIN Renyong
《医学前沿(英文)》 2007年 第1卷 第2期 页码 230-233 doi: 10.1007/s11684-007-0045-z
关键词: case-control significant difference reaction-restriction fragment C825T polymorphism evidence
Current molecular biologic techniques for characterizing environmental microbial community
Dawen GAO, Yu TAO
《环境科学与工程前沿(英文)》 2012年 第6卷 第1期 页码 82-97 doi: 10.1007/s11783-011-0306-6
关键词: molecular biological technique microbial community denaturing gradient gel electrophoresis (DGGE) terminal restriction fragment length polymorphism (T-RFLP) environmental applications
Xunan YANG, Shan HUANG, Qunhe WU, Renduo ZHANG, Guangli LIU
《环境科学与工程前沿(英文)》 2013年 第7卷 第6期 页码 851-859 doi: 10.1007/s11783-013-0569-1
关键词: heavy metals nutrients sediment profile terminal restriction fragment length polymorphism
Spatial and seasonal variations in bacterial communities of the Yellow Sea by T-RFLP analysis
Hongyuan WANG, Xiaolu JIANG, Ya HE, Huashi GUAN
《环境科学与工程前沿(英文)》 2009年 第3卷 第2期 页码 194-199 doi: 10.1007/s11783-009-0018-3
关键词:
terminal restriction fragment length polymorphism (T-RFLP)
bacterial community structure
marine microbial diversity
Response of bacterial communities to short-term pyrene exposure in red soil
Jingjing PENG, Hong LI, Jianqiang SU, Qiufang ZHANG, Junpeng RUI, Chao CAI
《环境科学与工程前沿(英文)》 2013年 第7卷 第4期 页码 559-567 doi: 10.1007/s11783-013-0501-8
关键词: pyrene bacterial communities terminal restriction fragment length polymorphism short-term exposure rank-abundance plots
Xiaohui WANG, Xianghua WEN, Hengjing YAN, Kun DING, Man HU
《环境科学与工程前沿(英文)》 2011年 第5卷 第1期 页码 92-98 doi: 10.1007/s11783-010-0254-6
关键词: ammonia-oxidizing bacteria (AOB) community dynamics terminal restriction fragment length polymorphism (T-RFLP) nitrification performance
Calorie restriction and its impact on gut microbial composition and global metabolism
Xiaojiao Zheng, Shouli Wang, Wei Jia
《医学前沿(英文)》 2018年 第12卷 第6期 页码 634-644 doi: 10.1007/s11684-018-0670-8
Calorie restriction (CR) is a dietary regimen that reduces calorie intake without incurring malnutrition or a reduction in essential nutrients. It has long been recognized as a natural strategy for promoting health, extending longevity, and prevents the development of metabolic and age-related diseases. In the present review, we focus on the general effect of CR on gut microbiota composition and global metabolism. We also propose mechanisms for its beneficial effect. Results showed that probiotic and butyrate-producing microbes increased their relative abundance, whereas proinflammatory strains exhibited suppressed relative abundance following CR. Analyses of the gut microbial and host metabolisms revealed that most host microbial co-metabolites were changed due to CR. Examples of dramatic CR-induced changes in host metabolism included a decrease in the rate of lipid biosynthesis and an increase in the rates of fatty acid catabolism, β-oxidation, glycogenolysis, and gluconeogenesis. The observed phenotypes and the further verification of the direct link between gut microbiota and metabolome may benefit patients that are at risk for developing metabolic disease. Thus, improved gut microbiota composition and metabolome are potential biomarkers for determining the effectiveness of dietary interventions for age-related and metabolic diseases.
null
《医学前沿(英文)》 2016年 第10卷 第2期 页码 204-211 doi: 10.1007/s11684-016-0443-1
CD176 (Thomsen-Friedenreich antigen) is a tumor-associated carbohydrate epitope (glycotope) functionally involved in blood spread and liver metastasis of cancer cells by mediating the adhesion of cancer cells to endothelial cells and hepatocytes, respectively. CD176 could be a promising target for antitumor immunotherapy. We applied B lymphocytes obtained from mice immunized with CD176 antigen and constructed a phage display library. A positive clone of CD176 single-chain variable antibody fragment (scFv) was successfully screened from this library. The CD176 scFv was expressed in Escherichia coli and purified. The purified scFv can bind to the natural CD176 expressed on the surface of cancer cells. Furthermore, the CD176 scFv inhibits the adhesion of CD176+ cancer cells to endothelial cells and hepatocytes. This CD176 scFv provides a basis for future development of recombinant CD176-specific antibodies that can be used in therapeutic application.
关键词: CD176 Thomsen-Friedenreich antigen scFv cancer therapy adhesion metastasis
《医学前沿(英文)》 2022年 第16卷 第3期 页码 378-388 doi: 10.1007/s11684-021-0840-y
关键词: severe Mycoplasma pneumoniae pneumonia children proteomics Fc fragment of the IgG-binding protein mechanistic target of rapamycin kinase inhibitor
Shutian LIU,Quhao LI,Wenjiong CHEN,Liyong TONG,Gengdong CHENG
《机械工程前沿(英文)》 2015年 第10卷 第2期 页码 126-137 doi: 10.1007/s11465-015-0340-3
Additive manufacturing (AM) technologies, such as selective laser sintering (SLS) and fused deposition modeling (FDM), have become the powerful tools for direct manufacturing of complex parts. This breakthrough in manufacturing technology makes the fabrication of new geometrical features and multiple materials possible. Past researches on designs and design methods often focused on how to obtain desired functional performance of the structures or parts, specific manufacturing capabilities as well as manufacturing constraints of AM were neglected. However, the inherent constraints in AM processes should be taken into account in design process. In this paper, the enclosed voids, one type of manufacturing constraints of AM, are investigated. In mathematics, enclosed voids restriction expressed as the solid structure is simply-connected. We propose an equivalent description of simply-connected constraint for avoiding enclosed voids in structures, named as virtual temperature method (VTM). In this method, suppose that the voids in structure are filled with a virtual heating material with high heat conductivity and solid areas are filled with another virtual material with low heat conductivity. Once the enclosed voids exist in structure, the maximum temperature value of structure will be very high. Based upon this method, the simply-connected constraint is equivalent to maximum temperature constraint. And this method can be easily used to formulate the simply-connected constraint in topology optimization. The effectiveness of this description method is illustrated by several examples. Based upon topology optimization, an example of 3D cantilever beam is used to illustrate the trade-off between manufacturability and functionality. Moreover, the three optimized structures are fabricated by FDM technology to indicate further the necessity of considering the simply-connected constraint in design phase for AM.
关键词: additive manufacturing topology optimization manufacturability constraints design for additive manufacturing simply-connected constraint
《化学科学与工程前沿(英文)》 2022年 第16卷 第12期 页码 1700-1712 doi: 10.1007/s11705-022-2207-6
关键词: naphtha catalytic pyrolysis reaction pathway equilibrium yield
Heterogeneous reaction mechanism of gaseous HNO
Nan ZHAO,Qingzhu ZHANG,Wenxing WANG
《环境科学与工程前沿(英文)》 2016年 第10卷 第5期 doi: 10.1007/s11783-016-0836-z
关键词: Seasalt particles NaCl HNO3 Heterogeneous reaction Reaction mechanism Density functional theory
Dual-reaction-center catalytic process continues Fenton’s story
Chao Lu, Kanglan Deng, Chun Hu, Lai Lyu
《环境科学与工程前沿(英文)》 2020年 第14卷 第5期 doi: 10.1007/s11783-020-1261-x
关键词: Dual reaction centers Fenton Pollutant utilization Electron transfer
标题 作者 时间 类型 操作
Association study on GNB3 gene polymorphism with essential hypertension in Xinjiang Uygur group
JING Jianying, WANG Dan, WANG Xiaofeng, JIN Jianzhong, JIN Li, JIAO Yi, WEN Hao, LIN Renyong
期刊论文
Current molecular biologic techniques for characterizing environmental microbial community
Dawen GAO, Yu TAO
期刊论文
Diversity and vertical distributions of sediment bacteria in an urban river contaminated by nutrients and heavy metals
Xunan YANG, Shan HUANG, Qunhe WU, Renduo ZHANG, Guangli LIU
期刊论文
Spatial and seasonal variations in bacterial communities of the Yellow Sea by T-RFLP analysis
Hongyuan WANG, Xiaolu JIANG, Ya HE, Huashi GUAN
期刊论文
Response of bacterial communities to short-term pyrene exposure in red soil
Jingjing PENG, Hong LI, Jianqiang SU, Qiufang ZHANG, Junpeng RUI, Chao CAI
期刊论文
Community dynamics of ammonia oxidizing bacteria in a full-scale wastewater treatment system with nitrification stability
Xiaohui WANG, Xianghua WEN, Hengjing YAN, Kun DING, Man HU
期刊论文
Calorie restriction and its impact on gut microbial composition and global metabolism
Xiaojiao Zheng, Shouli Wang, Wei Jia
期刊论文
CD176 single-chain variable antibody fragment inhibits the adhesion of cancer cells to endothelial cells
null
期刊论文
Proteomics study of Mycoplasma pneumoniae pneumonia reveals the Fc fragment of the IgG-binding protein
期刊论文
An identification method for enclosed voids restriction in manufacturability design for additive manufacturing
Shutian LIU,Quhao LI,Wenjiong CHEN,Liyong TONG,Gengdong CHENG
期刊论文
Thermodynamic analysis of reaction pathways and equilibrium yields for catalytic pyrolysis of naphtha
期刊论文